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Additional scientific questions that will need to be addressed include determining circulation residence time of the biosynthetic blood cell‐mimetic components, establishing pharmacokinetic (PK) and pharmacodynamic (PD) profiles utilizing appropriate preclinical models, and investigating feasibility and risks associated with repeat administration and escalating dose to determine maximum tolerated dose and therapeutic window

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[DOI] [PubMed] [Google Scholar] Smidt C.R., Unkefer C.J., Houck D.R., Rucker R.B