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For instance, a 4-year prospective study of over 4000 healthy men found that an increase in GGT was associated with an increased risk for diabetes, even while in its normal range

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Once activated, ERK1/2 is transferred to the nucleus, where it phosphorylates transcription factors such as c-Myc and c-Fos, leading to the expression of genes responsible for cellular regulations such as cell proliferation, differentiation, and migration